Light therapy is definitely experiencing a moment. Consumers can purchase glowing gadgets targeting issues like skin conditions and wrinkles as well as aching tissues and gum disease, the latest being a toothbrush enhanced with tiny red LEDs, described by its makers as “a major advance in personal mouth health.” Globally, the industry reached $1 billion in 2024 and is forecast to expand to $1.8 billion by 2035. Options include full-body infrared sauna sessions, where instead of hot coals (real or electric) heating the air, your body is warmed directly by infrared light. Based on supporter testimonials, it’s like bathing in one of those LED-lit beauty masks, boosting skin collagen, soothing sore muscles, reducing swelling and long-term ailments and potentially guarding against cognitive decline.
“It feels almost magical,” says a neuroscience expert, professor in neuroscience at Durham University and a convert to the value of light therapy. Naturally, certain impacts of light on human physiology are proven. Sunlight helps us make vitamin D, essential for skeletal strength, immune function, and muscular health. Sunlight regulates our circadian rhythms, additionally, activating brain chemicals and hormonal responses in daylight, and signaling the body to slow down for nighttime. Daylight-simulating devices are standard treatment for winter mood disorders to elevate spirits during colder months. Clearly, light energy is essential for optimal functioning.
Whereas seasonal affective disorder devices typically employ blue-range light, the majority of phototherapy tools use red or near-infrared wavelengths. In rigorous scientific studies, including research on infrared’s impact on neural cells, determining the precise frequency is essential. Light is a form of electromagnetic radiation, extending from long-wavelength radiation to the highest-energy (gamma waves). Phototherapy, or light therapy utilizes intermediate light frequencies, the highest energy of those being invisible ultraviolet, then visible light (all the colours we see in a rainbow) and finally infrared detectable with special equipment.
Ultraviolet treatment has been employed by skin specialists for decades for addressing long-term dermatological issues like vitiligo. It modulates intracellular immune mechanisms, “and dampens down inflammation,” notes a dermatology expert. “Considerable data validates phototherapy.” UVA goes deeper into the skin than UVB, whereas the LEDs we see on consumer light-therapy devices (which generally deliver red, infrared or blue light) “generally affect surface layers.”
The side-effects of UVB exposure, including sunburn or skin darkening, are well known but in medical devices the light is delivered in a “narrow-band” form – meaning smaller wavelengths – which decreases danger. “It’s supervised by a healthcare professional, thus exposure is controlled,” explains the dermatologist. Essentially, the light sources are adjusted by technical experts, “to guarantee appropriate wavelength emission – different from beauty salons, where it’s a bit unregulated, and we don’t really know what wavelengths are being used.”
Red and blue LEDs, he notes, “aren’t typically employed clinically, though they might benefit some issues.” Red light devices, some suggest, improve circulatory function, oxygen uptake and cell renewal in the skin, and promote collagen synthesis – an important goal for anti-aging. “The evidence is there,” states the dermatologist. “However, it’s limited.” Regardless, amid the sea of devices now available, “we don’t know whether or not the lights emitted are reflective of the research that has been done. Optimal treatment times are unknown, how close the lights should be to the skin, the risk-benefit ratio. Many uncertainties remain.”
One of the earliest blue-light products targeted Cutibacterium acnes, microorganisms connected to breakouts. Research support isn’t sufficient for standard medical recommendation – although, explains the specialist, “it’s frequently employed in beauty centers.” Some of his patients use it as part of their routine, he mentions, but if they’re buying a device for home use, “we advise cautious experimentation and safety verification. If it’s not medically certified, oversight remains ambiguous.”
Simultaneously, in innovative scientific domains, scientists have been studying cerebral tissue, discovering multiple mechanisms for infrared’s cellular benefits. “Pretty much everything I did with the light at that particular wavelength was positive and protective,” he reports. It is partly these many and varied positive effects on cellular health that have driven skepticism about light therapy – that results appear unrealistic. But his research has thoroughly changed his mind in that respect.
The researcher primarily focuses on pharmaceutical solutions for brain disorders, though twenty years earlier, a doctor developing photonic antiviral treatment consulted his scientific background. “He created some devices so that we could work with them with cells and with fruit flies,” he says. “I remained doubtful. The specific wavelength measured approximately 1070nm, that many assumed was biologically inert.”
Its beneficial characteristic, though, was its efficient water penetration, enabling deeper tissue penetration.
Growing data suggested infrared influenced energy-producing organelles. Mitochondria are the powerhouses of cells, producing fuel for biological processes. “All human cells contain mitochondria, including the brain,” says Chazot, who concentrated on cerebral applications. “Studies demonstrate enhanced cerebral circulation with light treatment, which is generally advantageous.”
With specific frequency application, cellular power plants create limited oxidative molecules. At controlled levels these compounds, explains the expert, “stimulates so-called chaperone proteins which look after your mitochondria, protect cellular integrity and manage defective proteins.”
All of these mechanisms appear promising for treating a brain disease: antioxidant, swelling control, and waste removal – autophagy representing cellular waste disposal.
Upon examining current studies on light therapy for dementia, he states, about 400 people were taking part in four studies, comprising his early research projects
A serial entrepreneur and startup advisor with over a decade of experience in tech innovation and venture capital.